The set-range for body composition that is determined by the central melanocortin system
varies from person to person and is influenced by both genetic and epigenetic factors. However, it seems that exposure to diets, particularly during childhood and adolescence, with their often
too much quantities of sugar and fatty acids can damage neuronal populations within the
hypothalamus and push the set-point for body fat more. This makes the overweight body composition appear to be the ‘new normal’ as far as the brain is concerned, and reverting to a leaner set-point once this has occurred can be very difficult.
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